If you’ve been told to take Primaquine, you probably have questions about why it’s needed and how to use it safely. This short guide breaks down the basics so you can feel confident about your treatment.
Primaquine is mainly used to stop malaria parasites from coming back after the main infection is treated. It works against the liver stage of P. vivax and P. ovale malaria, which can cause relapses weeks or months later. Doctors also give a single dose before you travel to a malaria‑risk area to stop you from catching the disease in the first place.
Besides malaria, some specialists use Primaquine for rare skin conditions and certain types of pneumonia, but those uses are less common. If your doctor mentioned a non‑malaria reason, ask how it works for that condition.
Dosage depends on why you’re taking it. For preventing relapses, adults usually get 15 mg of base daily for 14 days, or a single 30 mg dose for travel prophylaxis. Kids get weight‑based doses, so a child’s tablet may be split or a liquid formulation used.
Always take Primaquine with food or milk to reduce stomach upset. Swallow the tablet whole—don’t crush or chew it. If you miss a dose, take it as soon as you remember unless it’s almost time for the next one; then skip the missed dose and continue as scheduled.
Before starting, your doctor should test your blood for G6PD deficiency. People who lack this enzyme can develop severe hemolysis (red‑cell breakdown) when they take Primaquine. If you’ve never been tested, ask for the screening.
Common side effects are mild: nausea, headache, and dizziness. Most go away after a few days. If you notice dark urine, yellowing of the skin, or worsening fatigue, contact your doctor right away—those could be signs of hemolysis.
Drug interactions are possible. Antacids, certain antibiotics, and some heart medications can change how Primaquine works. Keep a list of all medicines and supplements you use and share it with your prescriber.
Pregnant women usually avoid Primaquine unless the benefits clearly outweigh the risks, because safety data are limited. Breast‑feeding mothers should also discuss it with their doctor.
While on Primaquine, avoid excessive sun exposure. Some people get a mild photosensitivity reaction, so wear a hat and sunscreen if you’ll be outdoors for long periods.
After you finish the course, you don’t need any special follow‑up unless you experienced side effects. However, if you travel again to a malaria‑endemic region, you’ll need a new prescription.
Remember, Primaquine is a powerful tool against malaria relapse, but it works only when you follow the dosing schedule and get screened for G6PD deficiency. Talk openly with your healthcare provider, ask about any concerns, and keep your medication handy while traveling.
